David A Flockhart

Title: Innovations of David A Flockhart

Introduction

David A Flockhart is an accomplished inventor based in Indianapolis, IN. He is known for his significant contributions to the field of pharmacogenetics, particularly in evaluating enzyme activity related to drug metabolism. His innovative approach has the potential to enhance personalized medicine by providing non-invasive methods for assessing metabolic capacity.

Latest Patents

David A Flockhart holds a patent for "Methods to evaluate cytochrome P450 2C19 isoenzyme activity using a breath test." This invention relates to a method of determining and assessing cytochrome P450 2C19-related metabolic capacity in an individual mammalian subject via a breath assay. The method involves determining the relative amount of carbon dioxide exhaled by the subject upon intravenous or oral administration of a carbon-labeled CYP2C19 substrate compound. This non-invasive assay is useful for evaluating CYP2C19 enzyme activity in subjects, aiding in the selection, optimal dosage, and timing of drug administration.

Career Highlights

Throughout his career, David has worked with notable organizations such as Cambridge Isotope Laboratories, Inc. and Indiana University. His work has significantly impacted the understanding of drug metabolism and personalized medicine.

Collaborations

David has collaborated with esteemed colleagues, including Zeruesenay Desta and Anil S Modak, contributing to advancements in pharmacogenetics and enzyme activity evaluation.

Conclusion

David A Flockhart's innovative work in evaluating cytochrome P450 2C19 isoenzyme activity has the potential to revolutionize personalized medicine. His contributions to the field highlight the importance of non-invasive testing methods in optimizing drug therapy for individuals.