This inventor holds 7 USPTO granted patents. Top assignees: Cepheid Corporation, Leland Stanford Junior University. Active years: 1999-2005.
Company Filing History:
Years Active: 1999-2005
Title: The Innovations of David A. Borkholder
Introduction
David A. Borkholder is a notable inventor based in San Jose, California. He has made significant contributions to the field of nucleic acid amplification, holding a total of seven patents. His work has advanced the methods used in molecular biology and diagnostics.
Latest Patents
Among his latest patents is an "Apparatus for analysis of a nucleic acid amplification reaction." This invention provides a mechanism for determining a threshold value in a nucleic acid amplification reaction. It includes a detection mechanism that measures signals at various times during the amplification process. The controller associated with this mechanism is programmed to store signal values that define a growth curve for the nucleic acid sequence. It also calculates a cycle number or time value related to the derivative of the growth curve.
Another significant patent is the "Method for quantitative analysis of a nucleic acid amplification reaction." This method involves amplifying an unknown starting quantity of a target nucleic acid sequence in a test sample. It also includes known starting quantities of a calibration nucleic acid sequence in calibration samples. The method determines a threshold value for each nucleic acid sequence using a derivative of the growth curve. Ultimately, it allows for the determination of the starting quantity of the target nucleic acid sequence in the test sample.
Career Highlights
David has worked with prominent organizations such as Cepheid Corporation and Leland Stanford Junior University. His experience in these institutions has contributed to his expertise in the field of molecular diagnostics and amplification technologies.
Collaborations
Throughout his career, David has collaborated with notable individuals, including William A. McMillan and Lee Allan Christel. These collaborations have further enriched his work and innovations in the field.
Conclusion
David A. Borkholder's contributions to the field of nucleic acid amplification are significant and impactful. His patents reflect a deep understanding of molecular biology and diagnostics, showcasing his role as an influential inventor.