This inventor holds 4 USPTO granted patents and 2 published patent applications. Top assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, University of California. Active years: 2003-2011.
Company Filing History:
2 out of 3,690 
2 out of 15,988 
Years Active: 2003-2011
Title: The Innovations of Darryl C Zeldin
Introduction
Darryl C Zeldin is a prominent inventor based in Chapel Hill, NC (US). He has made significant contributions to the field of biomedical research, particularly in the areas of diagnostics and therapeutics. With a total of 4 patents, Zeldin's work has the potential to impact various medical conditions.
Latest Patents
One of Zeldin's latest patents focuses on "Compositions and methods for diagnostics and therapeutics for hydrocephalus." This patent discusses the RFX4_v3 protein and the nucleic acids that encode it. The disclosure includes non-human transgenic animals with altered RFX4_v3 genes and assays for detecting RFX4_v3 and its polymorphisms associated with disease states. Additionally, it provides methods for determining a subject's risk of developing congenital hydrocephalus and strategies for treating or inhibiting its development.
Another significant patent by Zeldin is titled "Anti-inflammatory actions of cytochrome P450 expoxygenase-derived eicosanoids." This work highlights the role of epoxyeicosatrienoic acids (EETs), which are products of cytochrome P450 epoxygenases with vasodilatory properties. The patent identifies the cytochrome P450 isoform CYP2J2 as a source of EETs in human endothelial cells. Zeldin's research demonstrates that physiological concentrations of EETs can decrease cytokine-induced endothelial cell adhesion molecule expression, thereby preventing leukocyte adhesion to the vascular wall.
Career Highlights
Throughout his career, Zeldin has worked with notable organizations, including the United States Department of Health and Human Services and the University of California. His research has contributed to advancements in understanding vascular inflammation and hydrocephalus.
Collaborations
Zeldin has collaborated with esteemed colleagues such as Deanna Kroetz and Christophe H Morisseau. These partnerships have further enriched his research and innovation in the biomedical field.
Conclusion
Darryl C Zeldin's contributions to medical research through his patents and collaborations highlight his role as an influential inventor. His work continues to pave the way for advancements in diagnostics and therapeutics, particularly in addressing complex health issues.