Daniel J Simpson

Title: The Innovative Contributions of Daniel J Simpson

Introduction

Daniel J Simpson is a prominent inventor based in Middleton, WI (US), known for his significant contributions to the field of biochemistry and molecular biology. With a total of 17 patents to his name, he has developed innovative solutions that enhance the analysis and characterization of biological materials. His work has had a profound impact on various applications, particularly in the areas of protein digestion and stabilization.

Latest Patents

One of his latest patents is focused on cleavable surfactants. This invention provides surfactant compounds that can be utilized in methods for aiding the solubilization, digestion, preparation, analysis, and characterization of biological materials, such as proteins or cell membranes. The compounds are designed to assist in the recovery of peptides generated during protein digestion, especially for in-gel digestion protocols. Furthermore, these surfactants improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be decomposed by an acid, heat, or a combination of both, allowing for easy separation from isolated samples and facilitating analysis without compromising the sensitivity of various analytical techniques.

Another notable patent involves a method for stabilizing hemoglobin and reagents for performing the same. This invention includes a stool resuspension solution that comprises a hemoglobin stabilization reagent, which may consist of an osmolyte, a polyvalent cation, a sugar or polysaccharide, and optionally, a protoporphyrin or an HRP stabilization component. The method provides a way to stabilize hemoglobin in stool samples, along with a sample collection device containing the solution.

Career Highlights

Throughout his career, Daniel J Simpson has worked with reputable companies such as Promega Corporation and Exact Sciences Corporation. His experience in these organizations has allowed him to develop and refine his innovative ideas, contributing to advancements in the field.

Collaborations

Daniel has collaborated with notable colleagues, including Rex M Bitner and Roderick G Flemming, further enhancing the scope and impact of his work.

Conclusion

Daniel J Simpson's contributions to the field of biochemistry through his innovative patents demonstrate his commitment to advancing scientific knowledge and practical applications. His work continues to influence the way biological materials are analyzed and utilized in various research and clinical settings.