Location History:
- Jersey City, NJ (US) (1996)
- Glen Ridge, NJ (US) (2008)
- Upper Montclair, NJ (US) (2012)
Company Filing History:
Years Active: 1996-2012
Title: Innovations and Contributions of Daniel J Hicklin
Introduction
Daniel J Hicklin is a notable inventor based in Upper Montclair, NJ (US). He has made significant contributions to the field of biotechnology, particularly in the development of monoclonal antibodies. With a total of three patents to his name, Hicklin's work has the potential to impact the treatment of various angiogenic-related disorders.
Latest Patents
Hicklin's latest patents include groundbreaking inventions such as antibodies against vascular endothelial growth factor receptor-1. This patent details monoclonal antibodies that are specific for vascular endothelial growth factor receptor 1 (VEGFR-I). The invention also encompasses nucleotide sequences encoding and amino acid sequences comprising variable heavy and light chain immunoglobulin molecules. These sequences correspond to the complementarity determining regions of CDR1, CDR2, and CDR3. Furthermore, the invention provides methods for generating and expressing anti-VEGFR-I antibodies, as well as methods for treating angiogenic-related disorders and reducing tumor growth through the administration of these antibodies.
Another significant patent involves antibody antagonists of VE-cadherin without adverse effects on vascular permeability. The murine epitope sequence recognized by antibody E4B9 shares 100% homology with human VE-cadherin. This finding was confirmed through Western-blot analysis, which demonstrated that E4B9 cross-reacts with human VE-cadherin. This discovery facilitates the development of a 'humanized' E4B9 antibody, which can be extensively tested for its anti-tumor activity in various mouse models.
Career Highlights
Throughout his career, Hicklin has worked with prominent companies in the biotechnology sector, including Imclone Systems, Inc. and Imclone LLC. His experience in these organizations has contributed to his expertise in the field and has allowed him to advance his research and innovations.
Collaborations
Hicklin has collaborated with notable professionals in his field, including Peter Bohlen and Fang Liao. These collaborations have likely enriched his research and contributed to the success of his inventions.
Conclusion
Daniel J Hicklin's contributions to the field of biotechnology through his innovative patents and collaborations highlight his role as a significant inventor. His work in developing monoclonal antibodies has the potential to lead to advancements in the treatment of various medical conditions.