The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 13, 2008
Filed:
Jan. 02, 2002
Fang Liao, New York, NY (US);
Daniel J. Hicklin, Glen Ridge, NJ (US);
Peter Bohlen, New York, NY (US);
Fang Liao, New York, NY (US);
Daniel J. Hicklin, Glen Ridge, NJ (US);
Peter Bohlen, New York, NY (US);
Imclone Systems, Inc., New York, NY (US);
Abstract
The murine epitope sequence recognized by antibody E4B9 shares 100% homology with human VE-cadherin, so this antibody was examined to determine if it cross-reacts with human VIE-cadherin. Western-blot analysis of several VE-cadherin expressing human and murine ceH indicated that E4B9 indeed cross-reacts with human VE-cadherin (FIG.). This finding facilitates development of a 'humanized' E4B9 antibody and its success in the prectinical development since its anti-tumor activity can be tested extensively in several mouse models.