Daniel J Coleman

Title: The Innovative Contributions of Daniel J Coleman

Introduction

Daniel J Coleman is a prominent inventor based in Corvallis, OR (US). He has made significant contributions to the field of biochemistry, particularly in the visualization of acidic organelles. With a total of 6 patents to his name, Coleman's work has advanced our understanding of cellular processes.

Latest Patents

One of Coleman's latest patents focuses on enzyme substrates for visualizing acidic organelles. This invention relates to the visualization of acidic organelles based on organelle enzyme activity. The organelle substrates are specific for enzyme activity and label organelles, such as lysosomes, making them visible and easily observed. These substrates produce a fluorescent signal, designed to provide high fluorescence at low pH values. They are derivatized to allow membrane permeation through both outer and organelle membranes of intact cells. This innovation can be used for staining cells at very low concentrations and is non-toxic to living cells or tissues.

Career Highlights

Daniel J Coleman is associated with Marker Gene Technologies, Inc., where he continues to develop innovative solutions in the field of biochemistry. His work has been instrumental in enhancing the capabilities of researchers in visualizing cellular components.

Collaborations

Coleman has collaborated with notable colleagues, including John Joseph Naleway and Gabriele M Cook. These partnerships have contributed to the advancement of his research and the successful development of his patents.

Conclusion

Daniel J Coleman is a distinguished inventor whose work in enzyme substrates for visualizing acidic organelles has made a significant impact in the field of biochemistry. His contributions continue to influence research and innovation in cellular visualization techniques.