Daniel H Rich

Title: The Innovative Mind of Daniel H. Rich

Introduction

Daniel H. Rich is an accomplished inventor based in Madison, Wisconsin. With a remarkable portfolio of 12 patents, he has made significant contributions to the field of pharmaceutical chemistry, focusing particularly on compounds that hold promise for treating Alzheimer’s disease.

Latest Patents

Among his latest innovations are the patents for 3,4-disubstituted, 3,5-disubstituted, and 3,4,5-substituted piperidines. These inventions pertain to substituted piperidine, piperazine, morpholine, and thiomorpholine compounds, which are useful in targeting Alzheimer's disease. Specifically, his research centers on compounds that inhibit beta-secretase, an enzyme responsible for cleaving amyloid precursor protein, leading to the production of amyloid beta peptide (A-beta), a key component of amyloid plaques found in the brains of Alzheimer’s sufferers. The structural designs in the patents highlight compounds where Z is CR or N, with R, R, and R specifically detailed in the application.

In addition, Rich has developed methodologies for designing therapeutically important compounds. This innovation presents methods for generating non-peptide inhibitors of biologically active receptors, utilizing empirical three-dimensional data to construct receptor-ligand complex models. By altering the binding site's conformation, the process reveals new chemical structures complementary to these altered configurations, broadening the scope of potential therapeutic applications.

Career Highlights

Throughout his career, Daniel H. Rich has worked with prominent organizations, including the Wisconsin Alumni Research Foundation and The Boots Company Plc. These positions have enabled him to push the boundaries of medicinal chemistry further, laying the groundwork for future research and development in treating neurodegenerative diseases.

Collaborations

Rich has collaborated with notable professionals in his field, including Sweet K. Gurwara and Yvonne M. Angell. These partnerships have likely enhanced the innovation process, combining expertise to tackle complex challenges within the pharmaceutical industry.

Conclusion

Daniel H. Rich stands out as an influential inventor whose work holds great promise for advancing Alzheimer's treatment. His innovative patents and collaborative spirit within the industry are paving the way for significant enhancements in drug design and efficacy. With an ongoing commitment to research, Rich is likely to continue making impactful contributions to the medical field.