The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2008
Filed:
Nov. 19, 2002
Joseph B. Moon, Kalamazoo, MI (US);
Shon R. Pulley, Hickory Corners, MI (US);
Daniel H. Rich, Madison, WI (US);
David L. Brown, Chesterfield, MO (US);
Barbara Jagodzinska, Redwood City, CA (US);
Varghese John, San Francisco, CA (US);
John Jacobs, Kalamazoo, MI (US);
Joseph B. Moon, Kalamazoo, MI (US);
Shon R. Pulley, Hickory Corners, MI (US);
Daniel H. Rich, Madison, WI (US);
David L. Brown, Chesterfield, MO (US);
Barbara Jagodzinska, Redwood City, CA (US);
Varghese John, San Francisco, CA (US);
John Jacobs, Kalamazoo, MI (US);
Pharmacia & Upjohn Company, Kalamazoo, MI (US);
Elan Pharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: where Z is CR or N, and R, Rand Rare as described in the specification.