Company Filing History:
Years Active: 2021-2025
Title: The Innovative Contributions of Daniel Calarese
Introduction
Daniel Calarese is a prominent inventor based in Redwood City, CA (US). He has made significant contributions to the field of biotechnology, particularly in the development of engineered antibodies. With a total of 4 patents to his name, Calarese's work has the potential to impact therapeutic and diagnostic applications.
Latest Patents
One of his latest patents is titled "Antibodies with engineered CH2 domains, compositions thereof and methods of using the same." This patent focuses on antibodies and antibody conjugates that feature site-specific mutations in the CH2 domain of the heavy chain. The disclosed antibody variants exhibit improved characteristics such as thermal stability, antibody yields, and cell-killing capabilities compared to their parent or wild type counterparts. Additionally, pharmaceutical compositions, diagnostic compositions, and kits utilizing these antibodies are described for therapeutic and diagnostic purposes.
Another notable patent is "Anti-ROR1 antibody conjugates, compositions comprising anti ROR1 antibody conjugates, and methods of making and using anti-ROR1 antibody conjugates." This patent relates to antibodies and antibody conjugates that specifically bind to receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms. The patent outlines methods for producing these antibodies and their applications in therapeutic and diagnostic methods.
Career Highlights
Calarese is currently employed at Sutro Biopharma, Inc., where he continues to advance his research in antibody engineering. His work at Sutro Biopharma has positioned him as a key player in the biotechnology sector, contributing to innovative solutions in drug development.
Collaborations
Throughout his career, Calarese has collaborated with notable colleagues such as Gang Yin and Amandeep Gakhal. These collaborations have fostered a dynamic research environment, enhancing the development of cutting-edge biopharmaceuticals.
Conclusion
Daniel Calarese's innovative work in antibody engineering exemplifies the potential of biotechnology to transform therapeutic and diagnostic practices. His contributions through patents and collaborations continue to pave the way for advancements in the field.
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