Daniel Appledorn

Daniel Appledorn is a notable inventor based in Ann Arbor, MI, who has made significant contributions to the field of live cell analysis. With a total of five patents to his name, he has developed innovative methods and compositions that enhance our understanding of cellular processes.

Latest Patents

Among his latest patents, one focuses on "Methods and compositions for live cell analysis of intracellular ATP." This patent discloses ATP biosensor fusion proteins and their application in assaying ATP levels within cells. Another significant patent is titled "Live cell visualization and analysis," which provides systems and methods for automatically imaging and analyzing cell samples in an incubator. This technology utilizes an actuated microscope to generate images of samples over extended periods, allowing for detailed analysis of metabolically active cells. The analysis includes generating a 'range image' that highlights changes in cellular activity, particularly in neurons and cardiomyocytes, while minimizing interference from autofluorescence.

Career Highlights

Daniel has worked with prominent companies in the biotechnology sector, including Sartorius Bioanalytical Instruments, Inc. and Essen Instruments, Inc. His work in these organizations has contributed to advancements in bioanalytical technologies and live cell imaging.

Collaborations

Throughout his career, Daniel has collaborated with esteemed colleagues such as Kirk S. Schroeder and Eric William Endsley. These partnerships have fostered innovation and the development of cutting-edge technologies in cellular analysis.

Conclusion

Daniel Appledorn's contributions to live cell analysis and his innovative patents underscore his role as a leading inventor in the field. His work continues to impact the scientific community and enhance our understanding of cellular functions.

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