Location History:
- Silver Spring, MD (US) (2013)
- Bethesda, MD (US) (2015 - 2022)
- Stanford, CA (US) (2020 - 2024)
Company Filing History:
12 out of 3,539 
7 out of 5,309 
3 out of 40 
Years Active: 2013-2025
Title: The Innovative Contributions of Crystal L. Mackall
Introduction
Crystal L. Mackall, an accomplished inventor based in Bethesda, MD, has made significant strides in the field of cell therapy and oncology. With an impressive portfolio of 16 patents, her work focuses on developing innovative methods and compositions for treating cancer, particularly through the expansion of T cell populations.
Latest Patents
Among her latest patents, her work titled "Compositions and methods of expansion of T cell populations" presents breakthrough approaches to adoptive cell therapy. This invention outlines methods for producing a population of lymphocytes that are enriched in T stem cell memory cells, which demonstrate therapeutic effectiveness in treating various cancers. Furthermore, she has developed kits containing these compositions, which physicians can utilize to treat subjects diagnosed with or suspected to have cancer.
Another notable invention is related to "Bicistronic chimeric antigen receptors and their uses." This patent provides bicistronic chimeric antigen receptor (CAR) amino acid constructs, along with associated nucleic acids, recombinant expression vectors, and pharmaceutical compositions. The invention also details methods for detecting the presence of cancer and outlines treatments to prevent it in mammals, showcasing her commitment to advancing cancer therapies.
Career Highlights
Throughout her career, Crystal has collaborated with prestigious institutions such as the United States of America, represented by the Secretary of Health and Human Services, and Leland Stanford Junior University. Her work has significantly influenced the landscape of cancer treatment and cellular therapies, positioning her as a leader in her field.
Collaborations
Crystal has worked alongside esteemed colleagues like Rimas J. Orentas and Dimiter Stanchev Dimitrov, fostering a collaborative environment that encourages innovation and the development of groundbreaking solutions in cancer therapy.
Conclusion
Crystal L. Mackall's contributions to the understanding and treatment of cancer through her patents are reshaping how we approach oncology and cell therapies. Her dedication to innovation and collaboration continues to inspire the scientific community, paving the way for future discoveries that could transform patient care.