The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 2024
Filed:
May. 15, 2018
Applicant:
The United States of America,as Represented BY the Secretary,department of Health and Human Services, Bethesda, MD (US);
Inventors:
Haiying Qin, Potomac, MD (US);
Crystal L Mackall, Stanford, CA (US);
Terry J. Fry, Bethesda, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61P 35/00 (2006.01); C07K 14/395 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/395 (2013.01); C07K 14/7051 (2013.01); C07K 16/2803 (2013.01); C12N 15/85 (2013.01);
Abstract
An embodiment of the invention provides bicistronic chimeric antigen receptor (CAR) amino acid constructs. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CAR constructs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. Methods of making the CAR constructs are disclosed.