Cristina M Silva

Title: Cristina M Silva: Innovator in Cholinergic Dysfunction Research

Introduction

Cristina M Silva is a prominent inventor based in Belo Horizonte, Brazil. She has made significant contributions to the field of neuroscience, particularly in understanding cholinergic dysfunction and its implications for cognitive enhancement and myasthenia treatment. Her innovative work has led to the development of a unique patent that addresses critical issues in this area.

Latest Patents

Cristina holds a patent titled "Mouse model of cholinergic dysfunction to evaluate cognitive enhancers and drugs that improve myasthenia." This patent describes recombinant non-human mammals with reduced or no expression of vesicular acetylcholine transporter protein (VAChT) compared to their wild-type counterparts. These mammals exhibit impaired performance in object and social recognition, neuromuscular performance, and alterations in autonomic nervous system function. The patent also outlines methods for screening compounds for cholinergic activity and their potential in treating cholinergic neurotransmission disorders. Additionally, it provides details on isolated nerve cells and cell cultures useful for in vitro screening of candidate compounds.

Career Highlights

Cristina has worked at esteemed institutions such as Duke University and Universidade Federal De Minas Gerais. Her research has focused on the mechanisms underlying cholinergic neurotransmission and the development of therapeutic strategies for related disorders. Her work has garnered attention for its potential to improve treatment options for conditions like myasthenia gravis.

Collaborations

Throughout her career, Cristina has collaborated with notable researchers, including Marc G Caron and Vania F Prado. These collaborations have enriched her research and contributed to advancements in the understanding of cholinergic dysfunction.

Conclusion

Cristina M Silva is a trailblazer in the field of cholinergic dysfunction research, with a patent that holds promise for enhancing cognitive function and treating related disorders. Her contributions to neuroscience continue to pave the way for future innovations in this critical area.