The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2015
Filed:
Aug. 21, 2007
Marc G. Caron, Hillsborough, NC (US);
Vania F. Prado, Belo Horizonte, BR;
Marco A. Prado, Belo Horizonte, BR;
Raul Gainetdinov, Chapel Hill, NC (US);
Grace S. Pereira, Belo Horizonte, BR;
Braulio M. Castro, Belo Horizonte, BR;
Cristina M. Silva, Belo Horizonte, BR;
Ivan A. Izquierdo, Porto Alegre, BR;
Marc G. Caron, Hillsborough, NC (US);
Vania F. Prado, Belo Horizonte, BR;
Marco A. Prado, Belo Horizonte, BR;
Raul Gainetdinov, Chapel Hill, NC (US);
Grace S. Pereira, Belo Horizonte, BR;
Braulio M. Castro, Belo Horizonte, BR;
Cristina M. Silva, Belo Horizonte, BR;
Ivan A. Izquierdo, Porto Alegre, BR;
Duke University, Durham, NC (US);
Universidade Federal de Minas Gerais, Belo Horizonte, BR;
Abstract
Recombinant non-human mammals having reduced or no expression of vesicular acetylcholine transporter protein (VAChT) as compared to the corresponding wild-type mammal are provided. The mammal may have, e.g., impaired performance in object and social recognition and/or impaired neuromuscular performance and/or alterations in autonomic nervous system function as compared to the corresponding wild-type mammal. Methods of screening a compound for cholinergic activity or activity in treating a cholinergic neurotransmission disorder are also provided. In addition, a cell such as a nerve cell isolated from a mammal as described herein is provided, along with cell cultures, which are useful in vitro for screening the activity of candidate compounds for their effect on cholinergic neurotransmission, and for their activity in treating cholinergic neurotransmission disorders.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile