Company Filing History:
Years Active: 2008
Title: Cornelia Bellamacina: Innovator in Tie-2 Inhibitor Research
Introduction
Cornelia Bellamacina is a notable inventor based in Dedham, MA (US). She has made significant contributions to the field of biomedical research, particularly in the development of methods for identifying inhibitors of Tie-2, a receptor involved in angiogenesis and vascular development.
Latest Patents
Cornelia holds a patent for a "Method of identifying inhibitors of Tie-2." This invention relates to polypeptides that comprise the ligand binding domain of Tie-2, along with crystalline forms of these polypeptides. The patent outlines the use of these crystalline forms to determine the three-dimensional structure of the catalytic domain of Tie-2. Furthermore, it discusses the application of this three-dimensional structure, both alone and in complex with inhibitors, in designing and identifying potential inhibitors of Tie-2 activity. This includes compounds that inhibit the binding of a native substrate to the Tie-2 catalytic domain.
Career Highlights
Cornelia is currently associated with Abbott GmbH & Co. KG, where she continues her research and development efforts. Her work has been instrumental in advancing the understanding of Tie-2 and its implications in various medical conditions.
Collaborations
Cornelia has collaborated with esteemed colleagues, including Nancy J. Bump and Lee Daniel Arnold. These partnerships have enriched her research and contributed to the successful development of her patented methods.
Conclusion
Cornelia Bellamacina's innovative work in the field of Tie-2 inhibitors showcases her dedication to advancing biomedical research. Her contributions are paving the way for potential therapeutic applications in the future.