The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 06, 2008
Filed:
Mar. 22, 2001
Nancy J. Bump, Lowell, MA (US);
Lee D. Arnold, Westborough, MA (US);
Richard W. Dixon, Jefferson, MA (US);
Hans Wolfgang Hoeffken, Ludwigshafen, DE;
Karen Allen, Weston, MA (US);
Cornelia Bellamacina, Dedham, MA (US);
Nancy J. Bump, Lowell, MA (US);
Lee D. Arnold, Westborough, MA (US);
Richard W. Dixon, Jefferson, MA (US);
Hans Wolfgang Hoeffken, Ludwigshafen, DE;
Karen Allen, Weston, MA (US);
Cornelia Bellamacina, Dedham, MA (US);
Abbott GmbH & Co. KG, Wiesbaden, DE;
Abstract
The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The invention also relates to the use of the three dimensional structure of the Tie-2 catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Tie-2 activity, for example, compounds which inhibit the binding of a native substrate to the Tie-2 catalytic domain.