Constanza Pia Mangone

Title: Constanza Pia Mangone: Innovator in Solid State Chemistry

Introduction

Constanza Pia Mangone is a notable inventor based in Buenos Aires, Argentina. She has made significant contributions to the field of solid state chemistry, particularly in the development of pharmaceutical compounds. Her work has led to advancements in the preparation of important active ingredients used in various medications.

Latest Patents

Constanza holds a patent for "Solid and crystalline dutasteride and processes for preparation thereof." This patent focuses on the solid state chemistry of 17β-N-[2,5-bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5-α-androst-1-en-3-one, known as Dutasteride. Dutasteride is the active ingredient in products marketed under names such as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, and Duprost. The synthetic process she developed involves the formation of a mixed anhydride, followed by its reaction with 2,5-bis(trifluoromethyl)phenylamine in the presence of a suitable Lewis catalyst. The final steps include isolation, purification, and crystallization from acetonitrile and water.

Career Highlights

Throughout her career, Constanza has worked with prominent companies in the pharmaceutical industry, including Gador S.A. and Gador Sociedad Anonima. Her expertise in solid state chemistry has positioned her as a valuable asset in the development of innovative pharmaceutical solutions.

Collaborations

Constanza has collaborated with esteemed colleagues such as Dora Graciela Tombari and Maria Beatriz Garcia. These partnerships have contributed to her success and the advancement of her research in the field.

Conclusion

Constanza Pia Mangone is a pioneering inventor whose work in solid state chemistry has led to significant advancements in pharmaceutical preparations. Her contributions continue to impact the industry positively, showcasing her dedication to innovation and research.