The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8153648 B1

PDF
Full Text
Expired
Date of Patent:
Apr. 10, 2012

Filed:

Jan. 03, 2009
Applicants:

Dora Graciela Tombari, Buenos Aires, AR;

Constanza Pia Mangone, Buenos Aires, AR;

Maria Beatriz Garcia, Buenos Aires, AR;

Adriana Vechhioli, Buenos Aires, AR;

Rafael Alberto Labriola, Beccar, AR;

Inventors:

Dora Graciela Tombari, Buenos Aires, AR;

Constanza Pia Mangone, Buenos Aires, AR;

Maria Beatriz Garcia, Buenos Aires, AR;

Adriana Vechhioli, Buenos Aires, AR;

Rafael Alberto Labriola, Beccar, AR;

Assignee:

Gador S.A., Buenos Aires, AR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/473 (2006.01); C07D 221/18 (2006.01);
U.S. Cl.
CPC ...
Abstract

The solid state chemistry of 17β-N-[2,5-bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5-α-androst-1-en-3-one of which the international nonproprietary name is Dutasteride (the active ingredient in products marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) and its process for preparing. The synthetic process comprises formation of the mixed anhydride, its subsequent reaction with 2,5-bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst and its isolation, purification and crystallization from acetonitrile/water.


Find Patent Forward Citations

Tombari, Dora. (2012). Solid and crystalline dutasteride and processes for preparation thereof (U.S. Patent No. 8153648). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8153648

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…