The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 10, 2012
Filed:
Jan. 03, 2009
Dora Graciela Tombari, Buenos Aires, AR;
Constanza Pia Mangone, Buenos Aires, AR;
Maria Beatriz Garcia, Buenos Aires, AR;
Adriana Vechhioli, Buenos Aires, AR;
Rafael Alberto Labriola, Beccar, AR;
Dora Graciela Tombari, Buenos Aires, AR;
Constanza Pia Mangone, Buenos Aires, AR;
Maria Beatriz Garcia, Buenos Aires, AR;
Adriana Vechhioli, Buenos Aires, AR;
Rafael Alberto Labriola, Beccar, AR;
Gador S.A., Buenos Aires, AR;
Abstract
The solid state chemistry of 17β-N-[2,5-bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5-α-androst-1-en-3-one of which the international nonproprietary name is Dutasteride (the active ingredient in products marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) and its process for preparing. The synthetic process comprises formation of the mixed anhydride, its subsequent reaction with 2,5-bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst and its isolation, purification and crystallization from acetonitrile/water.