Company Filing History:
8 out of 76 
2 out of 363 
Years Active: 2000-2008
Title: **Innovator Spotlight: Colleen Siedem**
Introduction
Colleen Siedem is a prominent inventor based in Kennett Square, Pennsylvania, recognized for her significant contributions to the field of pharmaceuticals. With a remarkable portfolio comprising 10 patents, she has focused on developing innovative compounds aimed at various medical applications, particularly in the realm of protease inhibition.
Latest Patents
Among her latest patents, Colleen has been instrumental in the development of Heteroaryl aminoguanidines and alkoxyguanidines, which serve as potent protease inhibitors. These compounds, including those defined in her patent formula, are designed to inhibit proteolytic enzymes such as thrombin, which plays a critical role in blood coagulation. The invention encompasses methods for preparing these compounds, as well as their applications, which include inhibiting blood platelet loss and thrombus formation in mammals. Notably, some of these compounds display antithrombotic properties, potentially revolutionizing the management of blood-related conditions. Furthermore, these innovative compounds may find use as anticoagulants in various medical devices, such as catheters and blood dialysis machines, enhancing patient safety during blood collection and circulation.
Career Highlights
Colleen Siedem has enjoyed a successful career with key roles at notable organizations, including 3-Dimensional Pharmaceuticals, Inc. and Ortho-McNeil Pharmaceutical Corporation. Her work at these companies has fueled her research and patent development, allowing her to make a lasting impact in the pharmaceutical industry.
Collaborations
Throughout her career, Colleen has collaborated with several distinguished colleagues, including Tianbao Lu and Bruce Edward Tomczuk. These partnerships have aided her in advancing her research and contributed to her achievements in securing multiple patents.
Conclusion
Colleen Siedem stands out as an exemplary inventor whose innovative spirit has led to groundbreaking developments in medicine and biotechnology. Her dedication to creating novel protease inhibitors demonstrates her commitment to enhancing health outcomes and improving life quality for patients. As she continues to explore the potential of her inventions, the future of her contributions in the pharmaceutical sector looks promising.