Colin Bernard Reese

Title: Colin Bernard Reese – Innovating in the Field of Phosphorothioate Triesters

Introduction

Colin Bernard Reese, a notable inventor based in London, Great Britain, has made significant contributions to the field of organic chemistry. With a total of eight patents to his name, Reese has consistently focused on innovative processes that enhance the synthesis of complex chemical compounds, particularly in the realm of oligonucleotides.

Latest Patents

Reese's recent patents showcase his expertise in the preparation of phosphorothioate triesters. One of his notable inventions is a process for the synthesis of a phosphorothioate triester, involving the coupling of an H-phosphonate with an alcohol in the presence of both a coupling agent and a sulfur transfer agent. This innovative approach is particularly effective when the H-phosphonate and alcohol are protected nucleosides or oligonucleotides.

Another significant patent pertains to the solution phase synthesis of oligonucleotides. In this patented process, Reese outlines a method for synthesizing a phosphorothioate triester through the solution phase coupling of an H-phosphonate with an alcohol. The H-phosphonate diester formed is then oxidized in situ with a sulfur transfer agent, resulting in the production of the desired phosphorothioate triester. The versatility of this invention extends to the use of various oligonucleotide H-phosphonates crucial for the formation of these compounds.

Career Highlights

Colin Bernard Reese has built a distinguished career through his innovative research and contributions to the field. He has previously worked with reputable organizations such as Avecia Limited and King's College London, where he honed his expertise and contributed to the advancement of chemical synthesis techniques.

Collaborations

Collaboration is a vital aspect of Reese's career, and he has worked closely with his colleague Quanlai Song. Together, they have driven forward several projects that have led to significant advancements in the synthesis of oligonucleotides.

Conclusion

Colin Bernard Reese stands out as a leading figure in the development of innovative processes in organic chemistry. His eight patents, particularly in the realm of phosphorothioate triesters, reflect his commitment to enhancing chemical synthesis methods and underscore his impact on the field. Through his career and collaborations, Reese continues to contribute to scientific advancements that benefit both the research community and the industry.