The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 1995
Filed:
Mar. 29, 1993
Applicant:
Inventor:
Colin B Reese, London, GB;
Assignee:
Kings College London, London, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ;
U.S. Cl.
CPC ...
536 553 ; 536 253 ;
Abstract
A process for protecting the 2'-hydroxyl of a nucleoside, which can then be used in the chemical synthesis of polyribonucleotides, comprising the reacting of a protected nucleoside of formula I ##STR1## wherein B is a nucleoside heterocyclic base and R' is a hydroxyl-protecting group, with 1-N-aryl-4-alkoxy-1,2,5,6-tetrahydropiperidine of formula II ##STR2## wherein Ar is an aryl group possessing an electron-withdrawing substituent which renders said protecting group acid labile and R is C.sub.1 -C.sub.4 alkyl, in the presence of an acid catalyst and a solvent to yield the compound of formula II below: ##STR3##