Claire L Cofer

Title: Claire L Cofer: Innovator in Protein Expression Systems

Introduction

Claire L Cofer is a notable inventor based in Fremont, California. She has made significant contributions to the field of biotechnology, particularly in the development of expression systems for recombinant protein production. Her work has implications for various applications in medicine and research.

Latest Patents

Claire L Cofer holds a patent for a "Superior mammalian expression system." This innovative expression system utilizes CHO cells transformed with a DNA sequence that encodes the desired protein under the control of the human metallothionein-II promoter. The system allows for the maintenance of cells on serum-free medium and can be induced in the presence of an induction mediator. Additionally, it may include an enhancer element and/or a resistance-conferring gene to enhance expression levels. This system is capable of processing genomic as well as intronless DNA, producing proteins that exhibit characteristics similar to those obtained from native sources. Notably, human growth hormone indistinguishable from that produced by the pituitary has been successfully produced using this system.

Career Highlights

Claire has worked with California Biotechnology Inc., where she has been able to apply her expertise in protein expression systems. Her innovative approach has contributed to advancements in the field, making her a valuable asset to her company and the broader scientific community.

Collaborations

Throughout her career, Claire has collaborated with esteemed colleagues such as Peter J Kushner and Jeffrey S Friedman. These collaborations have further enriched her research and development efforts in biotechnology.

Conclusion

Claire L Cofer's contributions to the field of biotechnology, particularly through her patented expression system, highlight her role as an innovator in protein production. Her work continues to influence advancements in medical and research applications.