Christopher I Moore

Title: The Innovative Contributions of Christopher I Moore

Introduction

Christopher I Moore is a distinguished inventor based in Pawtucket, Rhode Island. He holds three patents that showcase his expertise in the field of biomedicine and optogenetics. His work focuses on developing innovative methods to control excitable cells, which have significant implications for treating various medical conditions.

Latest Patents

One of Moore's latest patents is titled "Minimally-invasive and activity-dependent control of excitable cells." This invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be expressed either in the excitable cell or in another cell proximal to the excitable cell. The methods of this invention can be used to desynchronize local activity of excitable cells in mammalian tissue. Furthermore, these methods can treat diseases or conditions related to bursting, such as Parkinson's disease, epilepsy, sleep disorders, or sensory-related conditions like attention deficit disorder or pain. Additionally, the invention includes a conjugate containing a voltage-gated ion channel and a luminescent protein.

Another significant patent by Moore is "Optogenetic control of endothelial cells." This invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The methods allow for the transport of therapeutics across the vascular barrier into tissues such as the brain and lung, with high spatial and temporal precision. Moreover, it enables the control of vascular properties such as vascular tone, arterial diameter, and vascular growth.

Career Highlights

Christopher I Moore has made substantial contributions to the field of biomedical research through his innovative patents. His work has been recognized in various academic and professional circles, highlighting his role as a leading inventor in optogenetics.

Collaborations

Moore has collaborated with notable institutions such as Brown University and the Massachusetts Institute of Technology. He has also worked alongside esteemed colleagues, including Tyler C Brown and Ute Hochgeschwender.

Conclusion

Christopher I Moore's innovative patents and contributions to the field of optogenetics demonstrate his commitment to advancing medical science. His work has the potential to significantly impact the treatment of various neurological and vascular conditions.