The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 2018
Filed:
Jun. 26, 2017
Applicants:
Brown University, Providence, RI (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Tyler C. Brown, Quincy, MA (US);
Christopher I. Moore, Pawtucket, RI (US);
Assignees:
Brown University, Providence, RI (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61N 5/06 (2006.01); A61K 41/00 (2006.01); A01K 67/027 (2006.01); C07K 14/47 (2006.01); C12M 1/42 (2006.01); A61K 48/00 (2006.01); A61N 5/067 (2006.01);
U.S. Cl.
CPC ...
A61N 5/062 (2013.01); A01K 67/0275 (2013.01); A61K 41/0057 (2013.01); A61N 5/0601 (2013.01); A61N 5/0618 (2013.01); C07K 14/4702 (2013.01); C12M 35/02 (2013.01); A01K 2217/052 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0393 (2013.01); A61K 48/005 (2013.01); A61N 2005/0602 (2013.01); A61N 2005/063 (2013.01); A61N 2005/067 (2013.01); A61N 2005/0652 (2013.01); A61N 2005/0663 (2013.01); C07K 2319/60 (2013.01); C12N 2799/021 (2013.01);
Abstract
The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth.