Company Filing History:
Years Active: 2015-2017
Title: Innovations of Inventor Christian Rudolph
Introduction
Christian Rudolph is an accomplished inventor based in Penzberg, Germany. He is recognized for his significant contributions to the field of RNA polymerases, holding two notable patents that demonstrate his expertise and innovative spirit.
Latest Patents
Rudolph's latest patents focus on T7 RNA polymerase variants with specific amino acid substitutions. The first patent provides novel variants of T7 RNA polymerase featuring a Cysteine-Serine substitution at position 723 of the amino acid sequence. These variants possess DNA-dependent RNA polymerase activity while exhibiting a reduced tendency to form intramolecular homodimers through oxidizing thiol groups. The innovations introduced by Rudolph are designed to maintain RNA polymerase activity while potentially improving the stability of the enzyme.
The second patent details improved T7 RNA polymerase variants enhanced for thermostability. By incorporating novel mutations at specific positions—Val426, Ser633, Val650, Thr654, Ala702, and Val795—Rudolph has demonstrated the opportunity for significant improvements in enzyme stability compared to the wild-type reference. These advancements have broad implications for various biochemical applications.
Career Highlights
Christian Rudolph is currently associated with Roche Diagnostics Operations, Inc., where he engages in innovative research and development. His career has been marked by a commitment to advancing enzymatic technologies and contributing to advancements in molecular biology.
Collaborations
In his professional journey, Rudolph has collaborated with notable colleagues such as Harald Sobek and Johann-Peter Thalhofer. Their combined expertise has fostered a collaborative environment, leading to impactful scientific advancements.
Conclusion
Through his pioneering work on T7 RNA polymerase variants, Christian Rudolph exemplifies the innovative spirit essential for scientific progress. His patents not only advance the understanding of RNA polymerases but also pave the way for their enhanced utility in research and application, fortifying his reputation as a significant inventor in the biotechnology field.