Location History:
- Bergschenhoek, NL (1993 - 1998)
- Nuenen, NL (1994 - 2000)
Company Filing History:
Years Active: 1993-2000
Title: Christiaan A Van Eekelen: Innovator in Genetic Engineering
Introduction
Christiaan A Van Eekelen is a notable inventor based in Bergschenhoek, Netherlands. He has made significant contributions to the field of genetic engineering, particularly in the area of prokaryotic gene amplification. With a total of five patents to his name, Van Eekelen's work has advanced the understanding and application of genetic modifications in microbial hosts.
Latest Patents
One of his latest patents focuses on stable gene amplification in chromosomal DNA of prokaryotic organisms. This innovation involves transformed prokaryotic hosts that contain two or more copies of a DNA sequence, which is stably maintained within their chromosome. The DNA sequence encodes a polypeptide of interest, with copies separated by endogenous chromosomal DNA sequences. The methods provided in this patent enable the production of transformed host strains that exhibit increased production of the desired polypeptide compared to existing host strains. Preferred host strains include Bacillus novo species PB92, known for producing a high-alkaline proteolytic enzyme, and B. licheniformis strain T5, which produces a thermostable alpha-amylase. The polypeptide encoding genes of interest are derived from these strains.
Career Highlights
Throughout his career, Christiaan A Van Eekelen has worked with prominent companies such as Gist-Brocades N.V. and DSM N.V. His experience in these organizations has allowed him to collaborate on various innovative projects, further enhancing his expertise in genetic engineering.
Collaborations
Some of his notable coworkers include Johannes C Van Der Laan and Leo J Mulleners. Their collaborative efforts have contributed to the advancement of research and development in the field.
Conclusion
Christiaan A Van Eekelen's contributions to genetic engineering through his patents and collaborations have made a significant impact in the field. His work continues to influence the development of advanced microbial strains for various applications.