Chin Yee Loh

Title: Innovations by Chin Yee Loh

Introduction

Chin Yee Loh is a notable inventor based in Kensington, California. He has made significant contributions to the field of biotechnology, particularly in the area of nuclear hormone receptor research. With a total of two patents to his name, Loh's work has the potential to advance our understanding of receptor activation and its implications in various biological processes.

Latest Patents

Chin Yee Loh's latest patents include innovative methods for detecting the binding of nuclear hormone receptors to coactivators and corepressors. One patent focuses on assays for nuclear hormone receptor binding, utilizing enzyme fragment complementation with fragments of β-galactosidase as the detection system. This method involves transforming cells to express a large fragment of β-galactosidase fused to a member of the complex with the nuclear hormone receptor, allowing for localization in the nucleus. The second patent, titled "Wild-type receptor assays," describes a method for determining ligand activation of receptors using cells that express genetic constructs of fusion proteins. These proteins facilitate the study of receptor activation and endocytosis upon stimulation with a ligand.

Career Highlights

Chin Yee Loh is currently employed at DiscoverX Corporation, where he continues to push the boundaries of research in receptor biology. His work has garnered attention for its innovative approaches and potential applications in drug discovery and therapeutic development.

Collaborations

Loh collaborates with esteemed colleagues such as Thomas S Wehrman and Mahesh Mathrubutham, contributing to a dynamic research environment that fosters innovation and discovery.

Conclusion

Chin Yee Loh's contributions to the field of biotechnology through his patents and collaborative efforts highlight his role as a significant inventor. His work not only advances scientific knowledge but also opens new avenues for therapeutic applications.