Title: Chin-Jen Ku: Innovator in Nucleic Acid Analysis
Introduction: Chin-Jen Ku is an accomplished inventor based in San Francisco, CA. He is currently associated with Clearnote Health, Inc. Despite having no granted patents, his work focuses on innovative methods for analyzing nucleic acids, which have significant implications in the medical field.
Latest Patent Applications: Chin-Jen Ku has filed several notable patent applications, including:
1. **Hydroxymethylation Analysis of Cell-Free Nucleic Acid Samples for Assigning Tissue of Origin, and Related Methods of Use** - This application describes a method for probabilistically assigning a tissue of origin to a nucleic acid in a sample, such as DNA in a cell-free fluid sample obtained from a human subject. The method involves generating a hydroxymethylation profile for the sample DNA and comparing it across a reference data set of hydroxymethylation profile vectors. This comparison allows for the probabilistic assignment of a tissue of origin to the sample nucleic acid.
2. **Pancreatic Ductal Adenocarcinoma Evaluation Using Cell-Free DNA Hydroxymethylation Profile** - This application discloses methods for identifying patients likely to have pancreatic ductal adenocarcinoma (PDAC) and those at risk for developing PDAC. The invention utilizes hydroxymethylation biomarkers, which, in combination with clinical parameters and patient-specific risk factors, correlate with the presence of or risk of developing PDAC.
Conclusion: Chin-Jen Ku is making significant strides in the field of nucleic acid analysis, with a focus on applications that could enhance patient diagnosis and treatment. His innovative approaches hold promise for advancing medical research and improving patient outcomes.
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