Company Filing History:
Years Active: 2021-2025
Title: Chester E Markwalter: Innovator in Nanoparticle Technology
Introduction
Chester E Markwalter is a prominent inventor based in Princeton, NJ (US). He has made significant contributions to the field of nanoparticle technology, holding a total of 3 patents. His work focuses on the development of innovative methods for encapsulating biologics and therapeutics, which have important implications in medical applications.
Latest Patents
Markwalter's latest patents include groundbreaking methods for creating triblock copolymer stabilizers that facilitate the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents. His first patent addresses the challenges faced by hydrophilic molecules, such as biologics, which often struggle with poor membrane permeability and rapid clearance from the bloodstream. The patent outlines methods for forming core-shell-brush nanoparticles using an A-B-C triblock copolymer, where the hydrophilic core contains the biologic, and the shell is formed from the precipitated B Block. This innovative approach allows for the tuning of release based on process parameters during particle assembly.
Another notable patent focuses on controlling the encapsulation efficiency and burst release of water-soluble molecules from nanoparticles and microparticles produced by the inverted Flash NanoPrecipitation (iFNP) process. This method allows for the adjustment of processing steps and materials to optimize encapsulation efficiency and release characteristics. The encapsulation efficiency and burst release can be influenced by various factors, including the copolymers used, the degree of crosslinking of the nanoparticle core, and the incorporation of additives.
Career Highlights
Chester E Markwalter is affiliated with Princeton University, where he continues to advance research in nanoparticle technology. His innovative work has positioned him as a key figure in the field, contributing to the development of new therapeutic delivery systems.
Collaborations
Markwalter has collaborated with notable colleagues, including Robert K Prud'homme and Robert F Pagels, further enhancing the impact of his research through teamwork and shared expertise.
Conclusion
Chester E Markwalter's contributions to nanoparticle technology and his innovative patents demonstrate his commitment to advancing medical applications through science. His work continues to influence the field and offers promising solutions for the challenges faced in therapeutic delivery.