Company Filing History:
Years Active: 1998-2003
Title: Innovations of Charles R. Ill
Introduction
Charles R. Ill is a notable inventor based in Encinitas, CA. He has made significant contributions to the field of biotechnology, particularly in the development of novel genes and vectors. With a total of 3 patents, his work has had a considerable impact on genetic research and therapeutic applications.
Latest Patents
One of his latest patents focuses on "Vectors and genes exhibiting increased expression." This patent discloses novel genes and vectors that exhibit increased expression and unique splicing patterns. The gene can include one or more consensus or near-consensus splice sites that have been corrected. Additionally, it may comprise one or more introns within coding or noncoding sequences. The gene can also feature modified 5′ and/or 3′ untranslated regions optimized for high levels and duration of tissue-specific expression. In a specific embodiment, the gene includes the coding region of a full-length Factor VIII gene, modified by adding an intron within the portion encoding the β-domain, resulting in the expression of a β-domain deleted Factor VIII protein. Furthermore, the novel Factor VIII gene can be modified to correct one or more consensus or near-consensus splice sites within or outside the coding region.
Another significant patent involves "Antisense constructs directed against viral post-transcriptional." This patent discloses antisense constructs aimed at viral cis-acting post-transcriptional regulatory sequences (PREs). In one embodiment, the antisense construct is an expression plasmid encoding one or more antisense transcripts that hybridize under intracellular conditions to all or part of a viral PRE within a viral transcript. The PRE functions to direct the export of the viral transcript from the nucleus to the cytoplasm of a cell. These antisense constructs can be utilized to inhibit viral production, such as HBV production.
Career Highlights
Charles R. Ill has been associated with The Immune Response Corporation, where he has contributed to groundbreaking research in immunology and virology. His work has been instrumental in advancing therapeutic strategies for various diseases.
Collaborations
Some of his notable coworkers include Scott Bidlingmaier and Jose E. Gonzales, who have collaborated with him on various projects within the company.
Conclusion
Charles R. Ill's innovative work in biotechnology and his contributions to the field through his patents highlight his role as a significant inventor.