The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 1998
Filed:
Mar. 11, 1996
Applicant:
Inventors:
Charles R Ill, Encinitas, CA (US);
Jose E Gonzales, San Diego, CA (US);
Assignee:
The Immune Response Corporation, Carlsbad, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N / ; C07H / ; C07H / ; C12P / ;
U.S. Cl.
CPC ...
4353201 ; 435 911 ; 536 241 ; 536 245 ;
Abstract
Antisense constructs ditrected against viral cis-acting post-transcriptional regulatory sequences ('PREs') are disclosed. In one embodiment, the antisense construct is an expression plasmid encoding one or more antisense transcripts which hybridize under intracellular conditions to all or a portion of a viral PRE within a viral transcript, the PRE having the function of directing export of the viral transcript from the nucleus to the cytoplasm of a cell. The antisense constructs can be used to inhibit viral production, such as HBV production.