Charles Lewis, Jr

Title: Charles Lewis, Jr.: Innovator in Cell Culture Technologies

Introduction

Charles Lewis, Jr. is a notable inventor based in Hazelwood, Missouri, recognized for his contributions to biological research and technology. With a total of five patents to his name, Lewis has made significant advancements in the field of cell culture and monoclonal antibody isolation.

Latest Patents

Two of Charles Lewis, Jr.’s latest patents highlight his innovative approach to cell culture technologies. The first, titled "Static Cell Culture Maintenance System," discloses a method and apparatus for keeping animal cells in vitro in a controlled state of proliferation while ensuring continuous secretion of cell products. The invention features a reactor vessel chamber where cells are retained in a semi-rigid matrix that allows for nutrient medium passage. Fresh nutrient medium is introduced via low porosity tubes, while spent medium and cell products are efficiently withdrawn through high porosity tubes, all within the reactor chamber. Additionally, an oxygenated gaseous medium is supplied through a selectively-permeable membrane, facilitating optimal cell growth.

The second patent focuses on a "Method of Isolating Monoclonal Antibodies from Hybridoma Cultures." This process involves isolating monoclonal antibodies from the spent culture medium of hybridoma cells by treating the medium with a cross-linked polyelectrolyte copolymer. This innovative method enhances the isolation and yield of monoclonal antibodies, which are vital for various research and therapeutic applications.

Career Highlights

Charles Lewis, Jr. is currently affiliated with Monsanto Company, where he contributes to research and development efforts that push the boundaries of agricultural biotechnology. His expertise and innovative spirit have played a crucial role in the company's objectives to enhance productivity and sustainability in farming practices.

Collaborations

Throughout his career, Lewis has collaborated with distinguished coworkers such as William R. Tolbert and James M. Schuck. These collaborations have allowed for the sharing of ideas and the pooling of expertise, fostering an environment where groundbreaking research can thrive and result in practical applications.

Conclusion

Charles Lewis, Jr. exemplifies the spirit of innovation through his work in cell culture technologies and antibody isolation methods. His patented inventions not only demonstrate his dedication to scientific advancement but also contribute to the broader field of biotechnological research. As a valued member of the Monsanto Company, Lewis continues to inspire future innovations in the industry.