Charles H Lochmuller

Title: The Innovations of Charles H. Lochmuller

Introduction

Charles H. Lochmuller is a notable inventor based in Durham, NC (US). He has made significant contributions to the field of enzyme technology and separation methods. With a total of 2 patents, his work showcases innovative approaches to complex scientific challenges.

Latest Patents

One of Lochmuller's latest patents is for a Carrageenan-immobilized esterase. This invention involves preparing carrageenan-immobilized enzymes that are stable and retain high activity toward substrates when used in substantially water-immiscible organic solvents. The process includes introducing droplets of an enzyme/carrageenan solution into chilled alcohol saturated with a potassium salt, which hardens the droplets. The alcohol can be selected from various options, including n-butanol and isopropanol. This invention allows for reactions catalyzed by a .kappa.-carrageenan-immobilized esterase, including stereoselective transesterifications and hydrolysis reactions.

Another significant patent is the ampholyte separation method and apparatus. This invention utilizes a thermally engendered pH gradient to separate amphoteric molecules based on their isoelectric points and mobilities. The apparatus features two independently temperature controllable thermal masses located on opposing ends of barriers situated transverse to a flow channel. This setup creates a pH gradient along the length of the barriers, allowing ampholytes to migrate and stabilize at points corresponding to their isoelectric points. The alteration of the pH gradient enables the separated molecules to reenter the flow stream at different times for collection.

Career Highlights

Throughout his career, Charles H. Lochmuller has worked with esteemed organizations such as Duke University and Andcare, Inc. His experience in these institutions has contributed to his innovative research and development in enzyme technology and separation methods.

Collaborations

Lochmuller has collaborated with notable colleagues, including Steven J. Breiner and Barbara S. Kitchell. These partnerships have likely enhanced his research and led to further advancements in his field.

Conclusion

Charles H. Lochmuller's contributions to enzyme technology and separation methods highlight his innovative spirit and dedication to scientific advancement. His patents reflect a deep understanding of complex biochemical processes and their applications.