Location History:
- Brookline, MA (US) (1997 - 2019)
- Bookline, MA (US) (2021)
Company Filing History:
11 out of 1,036 
1 out of 832,718 Years Active: 1997-2021
Title: **Charles B. Berde: Innovating Local Anesthesia**
Introduction
Charles B. Berde is an esteemed inventor based in Brookline, Massachusetts, with a prolific portfolio comprising 12 patents. His innovations primarily focus on enhancing pain management through improved local anesthesia techniques.
Latest Patents
Among his latest work, Berde developed formulations of Neosaxitoxin combination for prolonged local anesthesia. His research indicated that different site I sodium channel blockers have distinct activities, making it crucial to identify appropriate dosages for effective pain relief. The studies revealed that combining neosaxitoxin ('NeoSTX') with bupivacaine, either alone or with the addition of epinephrine, can yield pain relief lasting two to three days in humans. Notably, the NeoSTX-bupivacaine combinations provide a more reliable and longer duration blockade than NeoSTX alone. The triad of NeoSTX, bupivacaine, and epinephrine showcases enhanced effectiveness, significantly extending the duration of complete blockade to mechanical stimuli. These findings facilitated the development of specific combination dosage formulations.
Career Highlights
Charles Berde has played a critical role in advancing medical research and practices. His contributions have been particularly significant during his tenure at the Children's Medical Center Corporation, where he worked diligently on innovative solutions for pain management.
Collaborations
Berde's innovative journey has been enriched by collaborations with other prominent figures in the field, including Robert Samuel Langer and Daniel S. Kohane. Their collective efforts have undoubtedly propelled medical advancements and fostered a collaborative spirit in research and development.
Conclusion
In summary, Charles B. Berde stands out as a significant inventor whose work on local anesthesia continues to reshape pain management practices. His expertise and collaborative approach facilitate ongoing innovation, ultimately benefiting patients in need of effective pain relief.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.