Company Filing History:
Years Active: 2011
Title: Changshen Liu: Innovator in Recombinant Protein Technology
Introduction
Changshen Liu is a prominent inventor based in Shanghai, China. He has made significant contributions to the field of biotechnology, particularly in the development of optimized DNA sequences for recombinant proteins. His work has the potential to enhance therapeutic applications in regenerative medicine.
Latest Patents
Changshen Liu holds a patent for "Optimized DNA sequences encoding recombinant human bone morphogenetic protein-2 (rhBMP-2), preparation method and the uses thereof." This invention discloses an optimized DNA sequence of rhBMP-2 based on the expression system and a method for its preparation. The invention provides optimal DNA sequences suitable for expression systems, methods for efficient preparation of rhBMP-2, and related construction of recombinant bacteria, expression, and purification technologies. Compared to the traditional hBMP-2 gene, the expression level of the optimized gene increases by 50%. Additionally, this invention offers a method for preparing long-chain rhBMP-2 with enhanced renaturation efficiency and yield of purification.
Career Highlights
Changshen Liu is associated with Shanghai Rebone Biomaterials Co., Ltd., where he continues to innovate in the field of biomaterials. His work focuses on improving the efficacy of recombinant proteins, which are crucial for various medical applications.
Collaborations
Changshen Liu has collaborated with notable colleagues, including Jun Lin and Jiangchao Qian. Their combined expertise contributes to advancements in the field of biotechnology and regenerative medicine.
Conclusion
Changshen Liu's innovative work in optimizing DNA sequences for recombinant proteins represents a significant advancement in biotechnology. His contributions have the potential to improve therapeutic outcomes in regenerative medicine.
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