Location History:
- Houston, TX (US) (2014)
- Chicago, IL (US) (2019)
Company Filing History:
2 out of 5,501 
2 out of 193 
Years Active: 2014-2019
Title: Innovations by Catherine A O'Brian
Introduction
Catherine A O'Brian is a notable inventor based in Chicago, IL (US). She has made significant contributions to the field of peptide antigens, holding 2 patents that showcase her innovative approach to immunogenicity.
Latest Patents
One of her latest patents is focused on the controlled modulation of amino acid side chain length of peptide antigens. This invention provides a method for creating peptide antigens that include epitopes with modifications to the amino acid side chain. By extending or shortening the side chain using CH3/CH2 groups, and employing computer-assisted modeling of tumor antigens bound in the MHC-I-groove, the immunogenicity of these antigens can be enhanced. This method allows for minimal alteration of the adjacent tertiary structure, thereby reducing the risk of cross-reactivity. The invention also outlines methods for therapeutic or prophylactic treatment of various conditions through the administration of these antigens.
Career Highlights
Catherine has worked with esteemed organizations such as the University of Texas System and the Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. Her work in these institutions has furthered her research and development in the field of immunology.
Collaborations
Throughout her career, Catherine has collaborated with notable colleagues, including Constantin G Ioannides and Martin L Campbell. These partnerships have contributed to her innovative research and the advancement of her inventions.
Conclusion
Catherine A O'Brian's contributions to the field of peptide antigens demonstrate her commitment to innovation and research. Her patents reflect her expertise and the potential impact of her work on therapeutic treatments.