The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2019
Filed:
Jul. 29, 2014
Board of Regents, the University of Texas System, Austin, TX (US);
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Rockville, MD (US);
Constantin G. Ioannides, Houston, TX (US);
Martin L. Campbell, Colorado Springs, CO (US);
Catherine A. O'Brian, Chicago, IL (US);
George E. Peoples, San Antonio, TX (US);
Board of Regents, The University of Texas Systems, Austin, TX (US);
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Rockville, MD (US);
Abstract
The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension or shortening of the side chain with CH3/CH2 groups, for example, made by computer assisted modeling of the tumor antigen (peptide) bound in the MHC-I-groove, immunogenicity can be improved with minimal modification of adjacent tertiary structure, thereby avoiding cross-reactivity. Provided by the invention are methods of creating such antigens, as well as methods for therapeutic or prophylactic treatment of various conditions comprising administration of the antigens.