Casey J Krusemark

Title: Innovations by Casey J Krusemark

Introduction

Casey J Krusemark is an accomplished inventor based in Woodside, CA (US). She has made significant contributions to the field of mass spectrometry, holding a total of 3 patents. Her work focuses on enhancing the analysis of peptides and metabolites, which has important implications in various scientific fields.

Latest Patents

One of her latest patents is titled "Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis." This invention provides methods for enhancing the fragmentation of peptides for mass spectrometry by modifying the peptides with a tagging reagent containing a functional group, such as a tertiary amine. These high gas-phase basicity functional groups are attached to a peptide by reacting the tagging reagent to one or more available carboxylic acid groups of the peptide. This innovation leads to higher charge state ions from electrospray ionization mass spectrometry (ESI-MS), which fragment more extensively during fragmentation techniques.

Another notable patent is "Ionizable isotopic labeling reagents for relative quantification by mass spectrometry." This invention facilitates the relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS). It requires a mechanism for simultaneous analysis of multiple analytes in two or more samples. The labeled end-products generated higher signals concerning mass-spectra than precursor molecules, improving sensitivity and accuracy in quantification.

Career Highlights

Throughout her career, Casey has worked with prominent organizations such as the Wisconsin Alumni Research Foundation and the University of Illinois. Her work has significantly advanced the understanding and application of mass spectrometry in various scientific research areas.

Collaborations

Casey has collaborated with notable colleagues, including Lloyd M Smith and Brian L Frey. These collaborations have further enriched her research and contributed to her innovative patents.

Conclusion

Casey J Krusemark's contributions to mass spectrometry through her innovative patents demonstrate her expertise and commitment to advancing scientific research. Her work continues to influence the field and pave the way for future innovations.