Carol A Nelson

Title: Carol A Nelson: Innovator in Antisense Oligonucleotide Technology

Introduction

Carol A Nelson is a prominent inventor based in Westford, MA (US), known for her significant contributions to the field of antisense oligonucleotide technology. With a total of 8 patents to her name, she has made remarkable strides in developing therapeutic methods for diseases related to glycogen synthase.

Latest Patents

One of her latest patents focuses on inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides. This innovation relates to the modulation of glycogen synthase expression, which is crucial in treating diseases such as Pompe disease. The patent outlines compositions comprising antisense oligonucleotides and methods for downregulating mRNA coding for glycogen synthase, as well as methods for reducing glycogen synthase in skeletal and cardiac muscle. Another notable patent involves the conjugation of multiple phosphorodiamidate morpholino oligonucleotides to cationic cell-penetrating peptides, enhancing the uptake of these oligonucleotides into muscle cells.

Career Highlights

Throughout her career, Carol has worked with esteemed organizations such as Genzyme Corporation and the University of Michigan. Her work has significantly impacted the field of genetic therapies, particularly in the treatment of rare diseases.

Collaborations

Carol has collaborated with notable professionals in her field, including James A Shayman and David J Harris. These collaborations have further advanced her research and innovations in antisense oligonucleotide technology.

Conclusion

Carol A Nelson's contributions to the field of antisense oligonucleotides have paved the way for new therapeutic approaches to treat diseases associated with glycogen synthase. Her innovative patents and collaborations highlight her role as a leading inventor in this critical area of research.