The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 07, 2007
Filed:
Apr. 29, 2005
James A. Shayman, Ann Arbor, MI (US);
David J. Harris, Lexington, MA (US);
Craig Siegel, Woburn, MA (US);
Carol A. Nelson, Westford, MA (US);
Diane P. Copeland, North Billerica, MA (US);
James A. Shayman, Ann Arbor, MI (US);
David J. Harris, Lexington, MA (US);
Craig Siegel, Woburn, MA (US);
Carol A. Nelson, Westford, MA (US);
Diane P. Copeland, North Billerica, MA (US);
The Regents of the University of Michigan, Ann Arbor, MI (US);
Genzyme Corporation, Cambridge, MA (US);
Abstract
The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.