Company Filing History:
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1 out of 832,812 Years Active: 2010-2012
Title: Innovations of Carlos B Miguez
Introduction
Carlos B Miguez is a notable inventor based in Beaconsfield, CA. He has made significant contributions to the field of biotechnology, particularly in gene expression systems. With a total of 3 patents, Miguez has developed innovative methods that enhance protein production in various bacterial hosts.
Latest Patents
One of Miguez's latest patents is an inducible/regulated gene expression system in E. coli. This expression system allows for the transformation of E. coli with a nucleic acid molecule of interest, utilizing an operator sequence of a cmt operon linked to a promoter. Additionally, it incorporates a repressor sequence from a cym operon, also linked to a promoter. This system can be used to produce proteins by transforming E. coli host cells and culturing them under specific conditions that promote protein expression.
Another significant patent focuses on the regulation of heterologous recombinant protein expression in methylotrophic and methanotrophic bacteria. In this innovation, bacteria are transformed with a gene of interest, and the expression of this gene is regulated using a cumate repressor protein and an operator sequence linked to the gene. The addition of an external agent, such as cumate, allows for precise control over gene expression in these bacterial systems.
Career Highlights
Carlos B Miguez has worked with the National Research Council of Canada, where he has contributed to various research projects. His work has been instrumental in advancing the understanding of gene expression and protein production in microbial systems.
Collaborations
Throughout his career, Miguez has collaborated with notable colleagues, including Young-Jun Choi and Bernard Massie. These collaborations have further enriched his research and innovations in the field.
Conclusion
Carlos B Miguez is a distinguished inventor whose work in gene expression systems has paved the way for advancements in biotechnology. His innovative patents and collaborations highlight his commitment to enhancing protein production in microbial hosts.