Brussels, Belgium

Carl De Trez


Average Co-Inventor Count = 3.3

ph-index = 2

Forward Citations = 7(Granted Patents)


Company Filing History:


Years Active: 2012-2013

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2 patents (USPTO):Explore Patents

Title: Innovator Carl De Trez: Advancements in Immunology

Introduction: Carl De Trez, an accomplished inventor based in Brussels, Belgium, has made significant contributions to the field of immunology. With a focus on enhancing our understanding of immune responses, De Trez holds two patents that delve into complex mechanisms affecting T cell activation and dendritic cell populations.

Latest Patents: De Trez's latest patents include groundbreaking discoveries in the realm of immune modulation. One patent addresses "Compositions and methods for modulating responses mediated or associated with BTLA activity." This invention unveils a novel binding site for BTLA within the cysteine-rich domain-1 of the Herpesvirus entry mediator (HVEM). This molecular switch’s potential is further illustrated as it plays a crucial role in either propagating positive signals through LIGHT or inhibitory signals via BTLA, which has implications for T cell activation. The second patent involves "Methods for restoring dendritic cell populations." This invention elaborates on methods utilizing lymphotoxin-β receptor (LTβR) agonists to restore and increase dendritic cell populations in subjects, presenting promising treatment avenues for immunodeficiency.

Career Highlights: Carl De Trez is currently affiliated with the La Jolla Institute for Allergy and Immunology, where he engages in cutting-edge research to advance therapeutic solutions. His focus on the intricacies of the immune system and innovative approaches to modulation has distinguished him as a leading figure in his field.

Collaborations: Throughout his career, De Trez has collaborated with notable colleagues such as Carl F. Ware and Michael Croft, furthering research initiatives and contributing to the scientific community's understanding of immune system functions and therapies.

Conclusion: Carl De Trez's work exemplifies the essence of innovation in immunology. His patents reflect a deep commitment to understanding and manipulating immune responses, which may ultimately lead to significant advancements in treating immunological disorders. His contributions at the La Jolla Institute for Allergy and Immunology position him as an influential inventor in the field.

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