The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 08, 2013
Filed:
Jun. 10, 2009
Carl F. Ware, Solana Beach, CA (US);
Carl DE Trez, Brussels, BE;
Michael Croft, San Diego, CA (US);
Timothy C. Cheung, Sydney, AU;
Ian R. Humphreys, St. Brides Major, GB;
Karen G. Potter, San Diego, CA (US);
Christopher A. Benedict, Encinitas, CA (US);
Mitchell Kronenberg, Del Mar, CA (US);
Marcos W. Steinberg, San Diego, CA (US);
Carl F. Ware, Solana Beach, CA (US);
Carl De Trez, Brussels, BE;
Michael Croft, San Diego, CA (US);
Timothy C. Cheung, Sydney, AU;
Ian R. Humphreys, St. Brides Major, GB;
Karen G. Potter, San Diego, CA (US);
Christopher A. Benedict, Encinitas, CA (US);
Mitchell Kronenberg, Del Mar, CA (US);
Marcos W. Steinberg, San Diego, CA (US);
La Jolla Institute for Allergy and Immunology, La Jolla, CA (US);
Abstract
Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand, LIGHT (p30, TNFSF14), or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). A novel binding site for BTLA is disclosed, located in cysteine-rich domain-1 of HVEM. BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds, yet gD inhibits the binding of both ligands. A BTLA activating protein present in human cytomegalovirus is identified as UL144. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation.