Ian R Humphreys

Title: Ian R Humphreys: Innovator in Immunology

Introduction

Ian R Humphreys is a notable inventor based in St. Brides Major, GB. He has made significant contributions to the field of immunology, particularly through his research on the modulation of T cell activation.

Latest Patents

Humphreys holds a patent for "Compositions and methods for modulating responses mediated or associated with BTLA activity." This patent focuses on the Herpesvirus entry mediator (HVEM), which is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand, LIGHT, or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). His research discloses a novel binding site for BTLA located in cysteine-rich domain-1 of HVEM. The BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds. Notably, gD inhibits the binding of both ligands. Additionally, a BTLA activating protein present in human cytomegalovirus, identified as UL144, binds BTLA but not LIGHT, inhibiting T cell proliferation.

Career Highlights

Humphreys is affiliated with the La Jolla Institute for Allergy and Immunology, where he continues to advance research in immunology. His work has implications for understanding T cell responses and potential therapeutic applications.

Collaborations

Some of his notable coworkers include Carl F Ware and Carl De Trez, who have contributed to the research efforts in the field.

Conclusion

Ian R Humphreys is a distinguished inventor whose work in immunology has led to important advancements in understanding T cell modulation. His contributions continue to influence the field and pave the way for future innovations.