Bryan Dickinson

Title: Innovations of Bryan Dickinson

Introduction

Bryan Dickinson is an accomplished inventor based in Chicago, IL (US). He holds a total of 4 patents that showcase his contributions to the fields of biosensing and protease evolution. His work has significant implications for synthetic biology and bioengineering.

Latest Patents

One of his latest patents is titled "Proximity-dependent split RNA polymerases as a versatile biosensor platform." This invention describes a proximity-dependent split T7 RNA polymerase sensor that utilizes continuous molecular evolution. The versatility of this platform is highlighted by its ability to create robust light and small molecule-responsive genetic sensors. This activity-responsive RNA polymerase platform simplifies and expands the creation of genetic circuits, opening new opportunities in protein engineering, synthetic biology, and bioengineering.

Another notable patent is focused on the "Evolution of proteases." This disclosure provides methods for phage-assisted continuous evolution (PACE) of proteases. It includes strategies for evaluating and selecting protease inhibitors based on the likelihood of resistant proteases emerging. The methods also encompass fusion proteins that translate desired protease activity into a selective advantage for phage particles, along with improved mutagenesis-promoting expression constructs. Evolved proteases that recognize target cleavage sites differing from their canonical cleavage sites are also part of this innovation.

Career Highlights

Bryan Dickinson has worked at prestigious institutions such as Harvard College and the University of Chicago. His experience in these environments has contributed to his innovative research and development in the field of biosensors and protease evolution.

Collaborations

Throughout his career, Bryan has collaborated with notable individuals, including David R. Liu and Michael S. Packer. These collaborations have further enriched his research and expanded the impact of his inventions.

Conclusion

Bryan Dickinson's work exemplifies the intersection of innovation and practical application in the fields of biosensing and protease evolution. His contributions continue to influence advancements in synthetic biology and bioengineering.