The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2024
Filed:
Jun. 06, 2017
Applicant:
The University of Chicago, Chicago, IL (US);
Inventors:
Assignee:
The University of Chicago, Chicago, IL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/6897 (2018.01); C12N 9/12 (2006.01); C12Q 1/689 (2018.01); C12Q 1/48 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6897 (2013.01); C12N 9/1247 (2013.01); C12Q 1/48 (2013.01); C12Q 1/689 (2013.01); C12Y 207/07006 (2013.01);
Abstract
A proximity dependent split T7 RNAP (RNA polymerase) sensor using continuous molecular evolution is described. The versatility of the platform is described by creating robust light and small molecule-responsive genetic sensors. The activity-responsive RNAP platform dramatically simplifies and expands genetic circuit creation, and opens new opportunities in protein engineering, synthetic biology, and bioengineering.