Bryan A Kraynack

Title: Innovations of Bryan A Kraynack

Introduction

Bryan A Kraynack is a notable inventor based in San Diego, CA. He has made significant contributions to the field of gene modulation through his innovative patents. With a total of 2 patents, Kraynack's work focuses on the development of compositions that can effectively modulate gene expression.

Latest Patents

Kraynack's latest patents include "Double stranded constructs comprising one or more short strands hybridized to a longer strand." This invention provides compositions that include an antisense oligomeric compound hybridized to at least one shorter sense oligomeric compound. The sense oligomeric compounds can be covalently linked to the antisense oligomeric compounds, with a portion of the antisense oligomeric compound being complementary to and hybridizing with a nucleic acid target. Additionally, methods for modulating gene expression are provided using these compositions. Another significant patent is "Double stranded compositions comprising a 3'-endo modified strand for use in gene modulation." This invention offers double stranded compositions that have a region complementary to a target nucleic acid. One of the strands comprises linked ribofuranosyl nucleosides, while the other strand consists of linked modified nucleosides with 3'-endo conformational geometry. The strands can be linked together or remain separate and may contain additional groups, along with methods for using these compositions to modulate gene expression.

Career Highlights

Kraynack is currently associated with Isis Pharmaceuticals, Inc., where he continues to advance his research and innovations in the field of biotechnology. His work has garnered attention for its potential applications in gene therapy and molecular biology.

Collaborations

Some of his notable coworkers include Brenda F Baker and Balkrishen Bhat, who contribute to the collaborative environment at Isis Pharmaceuticals, Inc.

Conclusion

Bryan A Kraynack's contributions to gene modulation through his innovative patents highlight his role as a significant inventor in the biotechnology field. His work continues to pave the way for advancements in genetic research and therapy.