The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 07, 2010
Filed:
Jun. 03, 2004
Bryan A. Kraynack, San Diego, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Eric E. Swayze, Carlsbad, CA (US);
Richard H. Griffey, Vista, CA (US);
Bryan A. Kraynack, San Diego, CA (US);
Brenda F. Baker, Carlsbad, CA (US);
Balkrishen Bhat, Carlsbad, CA (US);
Eric E. Swayze, Carlsbad, CA (US);
Richard H. Griffey, Vista, CA (US);
Isis Pharmaceuticals, Inc., Carlsbad, CA (US);
Abstract
The present invention provides double stranded compositions that have a region that is complementary to a target nucleic acid. One of the targeting strand or the second strand comprises linked ribofuranosyl nucleosides and the other strand comprises linked modified nucleosides that have 3'-endo conformational geometry. The strands can be linked together or separate and may contain additional groups. The present invention also provides methods of using the compositions for modulating gene expression.