Bruce A McClane

Title: Bruce A McClane: Innovator in Clostridium Perfringens Research

Introduction

Bruce A McClane is a notable inventor based in Pittsburgh, PA (US). He has made significant contributions to the field of microbiology, particularly in the study of Clostridium perfringens and its associated toxins. His work has implications for treating and preventing food poisoning caused by this bacterium.

Latest Patents

Bruce A McClane holds a patent for a method involving Clostridium perfringens type A enterotoxin toxoid and methods of Escherichia coli strains that produce recombinant Clostridium perfringens type A enterotoxin toxoids. This invention details the process of subcloning a gene fragment encoding the Clostridium perfringens type A enterotoxin binding domain into an expression vector for forming plasmids. The resulting toxoids are designed to recognize and irreversibly bind to receptor sites on intestinal membranes, effectively competing with the Clostridium perfringens type A enterotoxin. This innovation may be used to treat symptoms of Clostridium perfringens food poisoning and includes the development of vaccines to prevent such symptoms.

Career Highlights

Bruce A McClane is affiliated with the University of Pittsburgh, where he continues to advance research in his field. His work has led to a better understanding of the mechanisms of Clostridium perfringens and the development of potential therapeutic interventions.

Collaborations

He has collaborated with notable colleagues, including Philip C Hanna and Timothy A Mietzner, to further enhance the research and applications of his inventions.

Conclusion

Bruce A McClane's innovative work in the field of microbiology has the potential to significantly impact the treatment and prevention of foodborne illnesses caused by Clostridium perfringens. His contributions are vital to advancing public health and safety.